Clinical utility of reticulocyte parameters.
نویسندگان
چکیده
The reticulocyte count reflects the erythropoietic activity of bone marrow and is thus useful in both diagnosing anemias and monitoring bone marrow response to therapy. Automated flow-cytometric analysis has led to a significant advance in reticulocyte counting, by simultaneously providing additional parameters and indices such as the reticulocyte immature reticulocyte fraction (IRF), the reticulocyte volume, and the hemoglobin content and concentration. IRF has been proposed as an early marker of engraftment. Reticulocyte hemoglobin content is useful in assessing the functional iron available for erythropoiesis, and reticulocyte volume is a useful indicator when monitoring the therapeutic response of anemias.
منابع مشابه
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Determination of the reticulocyte hemoglobin content (CHr) provides an early measure of functional iron deficiency because reticulocytes are the earliest erythrocytes released into blood and circulate for only 1 to 2 days. The CHr in 78 patients undergoing bone marrow examination was measured to assess its clinical utility for the diagnosis of iron deficiency. Twenty-eight patients were iron de...
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عنوان ژورنال:
- Clinics in laboratory medicine
دوره 35 1 شماره
صفحات -
تاریخ انتشار 2015